We report on CO and HI studies of the mixed-morphology supernova remnant (SNR) G346.6$-$0.2. We find a wind-blown bubble along the radio continuum shell with an expansion velocity of $sim10$ km s$^{-1}$, which was likely formed by strong stellar winds from the high-mass progenitor of the SNR. The radial velocities of the CO/HI bubbles at $V_mathrm{LSR} = -82$-$-59$ km s$^{-1}$ are also consistent with those of shock-excited 1720 MHz OH masers. The molecular cloud in the northeastern shell shows a high-kinetic temperature of $sim60$ K, suggesting that shock-heating occurred. The HI absorption studies imply that G346.6$-$0.2 is located on the far side of the Galactic center from us, and the kinematic distance of the SNR is derived to be $11.1_{-0.3}^{+0.5}$ kpc. We find that the CO line intensity has no specific correlation with the electron temperature of recombining plasma, implying that the recombining plasma in G346.6$-$0.2 was likely produced by adiabatic cooling. With our estimates of the interstellar proton density 280 cm$^{-3}$ and gamma-ray luminosity $< 5.8 times 10^{34}$ erg s$^{-1}$, the total energy of accelerated cosmic rays $W_{rm p} < 9.3 times 10^{47}$ erg is obtained. A comparison of the age-$W_{rm p}$ relation to other SNRs suggests that most of the accelerated cosmic rays in G346.6$-$0.2 have been escaped from the SNR shell.
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