High-angular resolution observations at sub-millimeter/millimeter wavelengths of disks surrounding young stars have shown that their morphology is made of azimuthally-symmetric or point-symmetric substructures, in some cases with spiral arms, localized spur- or crescent-shaped features. The majority of theoretical studies with the aim of interpreting the observational results have focused on disk models with planets, under the assumption that the disk substructures are due to the disk-planet interaction. However, so far only in very few cases exoplanets have been detected in these systems. Furthermore, some substructures are expected to appear textit{before} planets form, as they are necessary to drive the concentration of small solids which can lead to the formation of planetesimals. In this work we present observational predictions from high-resolution 3D radiative hydrodynamical models which follow the evolution of gas and solids in a protoplanetary disk. We focus on substructures in the distribution of millimeter-sized and smaller solid particles produced by the vertical shear instability. We show that their characteristics are compatible with some of the shallow gaps detected in recent observations at sub-mm/mm wavelengths, and present predictions for future observations with better sensitivity and angular resolution with ALMA and a Next Generation Very Large Array.