Lectures by the author at the 1986 Cargese summer school modestly corrected and uploaded for greater accessibility. Some of the authors views on the quantum mechanics of cosmology have changed from those presented here but may still be of historical interest. The material on the Born-Oppenheimer approximation for solving the Wheeler-DeWitt equation and the work on the classical geometry limit and the approximation of quantum field theory in curved spacetime are still of interest and of use.