There exists a number of astronomical spectral phenomena that have remained unidentified after decades of extensive observations. The diffuse interstellar bands, the 220 nm feature, unidentified infrared emission bands, extended red emissions, and 21 and 30 $mu$m emission features are seen in a wide variety of astrophysical environments. The strengths of these features suggest that they originate from chemical compounds made of common elements, possibly organic in nature. The quest to understand how such organic materials are synthesized and distributed across the Galaxy represents a major challenge to our understanding of the chemical content of the Universe.
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