With the advent of advancements in deep learning approaches, such as deep convolution neural network, residual neural network, adversarial network; U-Net architectures are most widely utilized in biomedical image segmentation to address the automation in identification and detection of the target regions or sub-regions. In recent studies, U-Net based approaches have illustrated state-of-the-art performance in different applications for the development of computer-aided diagnosis systems for early diagnosis and treatment of diseases such as brain tumor, lung cancer, alzheimer, breast cancer, etc. This article contributes to present the success of these approaches by describing the U-Net framework, followed by the comprehensive analysis of the U-Net variants for different medical imaging or modalities such as magnetic resonance imaging, X-ray, computerized tomography/computerized axial tomography, ultrasound, positron emission tomography, etc. Besides, this article also highlights the contribution of U-Net based frameworks in the on-going pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also known as COVID-19.
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