Contrastive learning has shown superior performance in embedding global and spatial invariant features in computer vision (e.g., image classification). However, its overall success of embedding local and spatial variant features is still limited, especially for semantic segmentation. In a per-pixel prediction task, more than one label can exist in a single image for segmentation (e.g., an image contains both cat, dog, and grass), thereby it is difficult to define positive or negative pairs in a canonical contrastive learning setting. In this paper, we propose an attention-guided supervised contrastive learning approach to highlight a single semantic object every time as the target. With our design, the same image can be embedded to different semantic clusters with semantic attention (i.e., coerce semantic masks) as an additional input channel. To achieve such attention, a novel two-stage training strategy is presented. We evaluate the proposed method on multi-organ medical image segmentation task, as our major task, with both in-house data and BTCV 2015 datasets. Comparing with the supervised and semi-supervised training state-of-the-art in the backbone of ResNet-50, our proposed pipeline yields substantial improvement of 5.53% and 6.09% in Dice score for both medical image segmentation cohorts respectively. The performance of the proposed method on natural images is assessed via PASCAL VOC 2012 dataset, and achieves 2.75% substantial improvement.
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