Natural silver targets have been irradiated by using a 50 MeV alpha-particle beam in order to measure the activation cross sections of radioisotopes in the 40-50 MeV energy range. Among the radio-products there are medically important isotopes such as $^{110m}$In and $^{111}$In. For optimizing the production of these radioisotopes and regarding their purity and specific activity the cross section data for every produced radioisotope are important. New data are measured in this energy range and the results of some previous measurements have been confirmed. Physical yield curves have been calculated by using the new cross section data completed with the results from the literature.
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