Objective. Modelling is an important way to study the working mechanism of brain. While the characterization and understanding of brain are still inadequate. This study tried to build a model of brain from the perspective of thermodynamics at system level, which brought a new thinking to brain modelling. Approach. Regarding brain regions as systems, voxels as particles, and intensity of signals as energy of particles, the thermodynamic model of brain was built based on canonical ensemble theory. Two pairs of activated regions and two pairs of inactivated brain regions were selected for comparison in this study, and the analysis on thermodynamic properties based on the model proposed were performed. In addition, the thermodynamic properties were also extracted as input features for the detection of Alzheimers disease. Main results. The experiment results verified the assumption that the brain also follows the thermodynamic laws. It demonstrated the feasibility and rationality of brain thermodynamic modelling method proposed, indicating that thermodynamic parameters could be applied to describe the state of neural system. Meanwhile, the brain thermodynamic model achieved much better accuracy in detection of Alzheimers disease, suggesting the potential application of thermodynamic model in auxiliary diagnosis. Significance. (1) Instead of applying some thermodynamic parameters to analyze neural system, a brain model at system level was proposed from perspective of thermodynamics for the first time in this study. (2) The study discovered that the neural system also follows the laws of thermodynamics, which leads to increased internal energy, increased free energy and decreased entropy when system is activated. (3) The detection of neural disease was demonstrated to be benefit from thermodynamic model, implying the immense potential of thermodynamics in auxiliary diagnosis.
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