There are two puzzles surrounding the Pleiades, or Seven Sisters. First, why are the mythological stories surrounding them, typically involving seven young girls being chased by a man associated with the constellation Orion, so similar in vastly separated cultures, such as the Australian Aboriginal cultures and Greek mythology? Second, why do most cultures call them Seven Sisters even though most people with good eyesight see only six stars? Here we show that both these puzzles may be explained by a combination of the great antiquity of the stories combined with the proper motion of the stars, and that these stories may predate the departure of most modern humans out of Africa around 100,000 BC.