In this article, we overview intelligent reflecting surface (IRS)-empowered wireless communication systems. We first present the fundamentals of IRS-assisted wireless transmission. On this basis, we explore the integration of IRS with various advanced transmission technologies, such as millimeter wave, non-orthogonal multiple access, and physical layer security. Following this, we discuss the effects of hardware impairments and imperfect channel-state-information on the IRS system performance. Finally, we highlight several open issues to be addressed.