We introduce Prove-It, a Python-based general-purpose interactive theorem-proving assistant designed with the goal of making formal theorem proving as easy and natural as informal theorem proving (with moderate training). Prove-It uses a highly-flexible Jupyter notebook-based user interface that documents interactions and proof steps using LaTeX. We review Prove-Its highly expressive representation of expressions, judgments, theorems, and proofs; demonstrate the system by constructing a traditional proof-by-contradiction that $sqrt{2} otinmathbb{Q}$; and discuss how the system avoids inconsistencies such as Russells and Currys paradoxes. Extensive documentation is provided in the appendices about core elements of the system. Current development and future work includes promising applications to quantum circuit manipulation and quantum algorithm verification.