The Simons Observatory (SO) will observe the cosmic microwave background (CMB) from Cerro Toco in the Atacama Desert of Chile. The observatory consists of three 0.5 m Small Aperture Telescopes (SATs) and one 6 m Large Aperture Telescope (LAT), covering six frequency bands centering around 30, 40, 90, 150, 230, and 280 GHz. The SO observations will transform the understanding of our universe by characterizing the properties of the early universe, measuring the number of relativistic species and the mass of neutrinos, improving our understanding of galaxy evolution, and constraining the properties of cosmic reionization. As a critical instrument, the Large Aperture Telescope Receiver (LATR) is designed to cool $sim$ 60,000 transition-edge sensors (TES) to $<$ 100 mK on a 1.7 m diameter focal plane. The unprecedented scale of the LATR drives a complex design. In this paper, we will first provide an overview of the LATR design. Integration and validation of the LATR design are discussed in detail, including mechanical strength, optical alignment, and cryogenic performance of the five cryogenic stages (80 K, 40 K, 4 K, 1 K, and 100 mK). We will also discuss the microwave-multiplexing ($mu$Mux) readout system implemented in the LATR and demonstrate the operation of dark prototype TES bolometers. The $mu$Mux readout technology enables one coaxial loop to read out $mathcal{O}(10^3)$ TES detectors. Its implementation within the LATR serves as a critical validation for the complex RF chain design. The successful validation of the LATR performance is not only a critical milestone within the Simons Observatory, it also provides a valuable reference for other experiments, e.g. CCAT-prime and CMB-S4.
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