We show that the onset of quantum chaos at infinite temperature in two many-body 1D lattice models, the perturbed spin-1/2 XXZ and Anderson models, is characterized by universal behavior. Specifically, we show that the onset of quantum chaos is marked by maxima of the typical fidelity susceptibilities that scale with the square of the inverse average level spacing, saturating their upper bound, and that the strength of the integrability/localization breaking perturbation at these maxima decreases with increasing system size. We also show that the spectral function below the Thouless energy (in the quantum-chaotic regime) diverges when approaching those maxima. Our results suggest that, in the thermodynamic limit, arbitrarily small integrability/localization breaking perturbations result in quantum chaos in the many-body quantum systems studied here.