The most robust prediction of inflationary cosmology is the existence of a red tilt for the spectrum of curvature fluctuations that is experimentally of order $0.04$. The tilt is derived solving the exact equation for quantum fluctuations in a quasi de Sitter background defined by a equation of state $epsilon equiv frac{(p+rho)}{rho}$ with $epsilon$ small but non vanishing. The experimental data selects among the different quasi de Sitter inflaton potentials. The origin of the lack of scale invariance associated with the tilt is however classical in essence and parametrized by the slow roll of the inflaton potential. Here we present a purely quantum mechanical and model independent derivation of the tilt. This derivation is based on two basic observations: first, the correlator for gauge invariant variables is related to the {it quantum Fisher function} measuring the quantum dependence of the family of pure de Sitter vacua on the energy scale parameter; second, this quantum Fisher function has a non vanishing scale dependent red tilt that, at the energy scales of physical interest, fits the effective quasi de Sitter prediction as well as the experimental value. This is a result that is model independent and only based on the quantum features of the family of de Sitter vacua.
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