We present the first lattice-QCD calculation of the nucleon isovector unpolarized parton distribution functions (PDFs) at the physical-continuum limit using Large-Momentum Effective Theory (LaMET). The lattice results are calculated using ensembles with multiple sea pion masses with the lightest one around 135~MeV, 3 lattice spacings $ain[0.06,0.12]$~fm, and multiple volumes with $M_pi L$ ranging 3.3 to 5.5. We perform a simultaneous chiral-continuum extrapolation to obtain RI/MOM renormalized nucleon matrix elements with various Wilson-link displacements in the continuum limit at physical pion mass. Then, we apply one-loop perturbative matching to the quasi-PDFs to obtain the lightcone PDFs. We find the lattice-spacing dependence to be much larger than the dependence on pion mass and lattice volume for these LaMET matrix elements. Our physical-continuum limit unpolarized isovector nucleon PDFs are found to be consistent with global-PDF results.