Since 2006 the theory of slice hyperholomorphic functions and the related spectral theory on the S-spectrum have had a very fast development. This new spectral theory based on the S-spectrum has applications for example in the formulation of quaternionic quantum mechanics, in Schur analysis and in fractional diffusion problems. The notion of poly slice analytic function has been recently introduced for the quaternionic setting. In this paper we study the theory of poly slice monogenic functions and the associated functional calculus, called PS-functional calculus, which is the polyanalytic version of the S-functional calculus. Also for this poly monogenic functional calculus we use the notion of S-spectrum.