We propose the use of isotopically highly enriched detectors for the precise study of coherent-elastic neutrino-nucleus scattering (CEvNS). CEvNS has been measured for the first time in CsI and recently confirmed with a liquid argon detector. It is expected that several new experimental setups will measure this process with increasing accuracy. Taking Ge detectors as a working example, we demonstrate that a combination of different isotopes is an excellent option to probe, for instance, the dominant quadratic dependence on the number of neutrons, $N$, that is predicted by the theoretical models. This is only an example, but the scheme has much more general applicability. Experiments based on the new approach can make a simultaneous differential CEvNS measurements with detectors of different isotopic composition. Particular combination of observables could be used to cancel systematic errors.
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