Late gadolinium enhancement (LGE) cardiac MRI (CMR) is the clinical standard for diagnosis of myocardial scar. 3D isotropic LGE CMR provides improved coverage and resolution compared to 2D imaging. However, image acceleration is required due to long scan times and contrast washout. Physics-guided deep learning (PG-DL) approaches have recently emerged as an improved accelerated MRI strategy. Training of PG-DL methods is typically performed in supervised manner requiring fully-sampled data as reference, which is challenging in 3D LGE CMR. Recently, a self-supervised learning approach was proposed to enable training PG-DL techniques without fully-sampled data. In this work, we extend this self-supervised learning approach to 3D imaging, while tackling challenges related to small training database sizes of 3D volumes. Results and a reader study on prospectively accelerated 3D LGE show that the proposed approach at 6-fold acceleration outperforms the clinically utilized compressed sensing approach at 3-fold acceleration.
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