In this paper, we present a dual-channel serializer ASIC, LOCx2, and its pin-compatible backup, LOCx2-130, for detector front-end readout. LOCx2 is fabricated in a 0.25-um Silicon-on-Sapphire CMOS process and each channel operates at 5.12 Gbps, while LOCx2-130 is fabricated in a 130-nm bulk CMOS process and each channel operates at 4.8 Gbps. The power consumption and the transmission latency are 900 mW and 27 ns for LOCx2 and the corresponding simulation result of LOCx2-130 are 386 mW and 38 ns, respectively.