We demonstrate the rise-and-fall of multiple pseudogaps in the Bardeen-Cooper-Schrieffer-Bose-Einstein-condensation (BCS-BEC) crossover in two-band fermionic systems having different pairing strengths in the deep band and in the shallow band. The striking features of this phenomenon are an unusual many-body screening of pseudogap state and the importance of pair-exchange couplings, which induces multiple pseudogap formation in the two bands. The multi-band configuration suppresses pairing fluctuations and the pseudogap opening in the strongly-interacting shallow band at small pair-exchange couplings by screening effects, with possible connection to the pseudogap phenomenology in iron based superconductors. On the other hand, the multiple pseudogap mechanism accompanies with the emergence of binary preformed Cooper pairs originating from interplay between intra-band and pair-exchange couplings.