We evaluate the cross section for the pion induced Drell-Yan process in two different models of the pion light-front wave function, inspired by light-front holographic approaches. We obtain the valence quark distribution functions in those models, which after QCD evolution, are consistent with the experimental data from the E-0615 experiment at Fermilab. Supplemented by the parton distribution functions of the target nuclei, we obtain the cross section consistent with the experimental data for the $pi^-$ Nucleus $rightarrow {mu^+mu^-X}$ Drell-Yan process.
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