We present [Fe/H] and [$alpha$/Fe] abundances, derived using spectral synthesis techniques, for stars in M31s outer stellar halo. The 21 [Fe/H] measurements and 7 [$alpha$/Fe] measurements are drawn from fields ranging from 43 to 165 kpc in projected distance from M31. We combine our measurements with existing literature measurements, and compare the resulting sample of 23 stars with [Fe/H] and 9 stars with [$alpha$/Fe] measurements in M31s outer halo with [$alpha$/Fe] and [Fe/H] measurements, also derived from spectral synthesis, in M31s inner stellar halo ($r < $26 kpc) and dSph galaxies. The stars in M31s outer halo have [$alpha$/Fe] patterns that are consistent with the largest of M31s dSph satellites (And I and And VII). These abundances provide tentative evidence that the [$alpha$/Fe] abundances of stars in M31s outer halo are more similar to the abundances of Milky Way halo stars than to the abundances of stars in M31s inner halo. We also compare the spectral synthesis-based [Fe/H] measurements of stars in M31s halo with previous photometric [Fe/H] estimates, as a function of projected distance from M31. The spectral synthesis-based [Fe/H] measurements are consistent with a large-scale metallicity gradient previously observed in M31s stellar halo to projected distances as large as 100 kpc.