We study uniform exponential growth of groups acting on CAT(0) cube complexes. We show that groups acting without global fixed points on CAT(0) square complexes either have uniform exponential growth or stabilize a Euclidean subcomplex. This generalizes the work of Kar and Sageev considers free actions. Our result lets us show uniform exponential growth for certain groups that act improperly on CAT(0) square complexes, namely, finitely generated subgroups of the Higman group and triangle-free Artin groups. We also obtain that non-virtually abelian groups acting freely on CAT(0) cube complexes of any dimension with isolated flats that admit a geometric group action have uniform exponential growth.