Nonreciprocal microwave devices, such as circulators and isolators, are critical in high-fidelity qubit readout schemes. They unidirectionally route the readout signals and protect the qubits against noise coming from the output chain. However, cryogenic circulators and isolators are prohibitive in scalable superconducting architectures because they rely on magneto-optical effects. Here, we realize an on-chip, single-microwave-pump Josephson ISolator (JIS), formed by coupling two nondegenerate Josephson mixers in an interferometric scheme. We unravel the interplay between the orientation parity of the magnetic fluxes, biasing the mixers, and the JIS directionality. Furthermore, we build a motherboard, which integrates the JIS and other superconducting components, including a Josephson directional amplifier, into a printed circuit and use it to read out a qubit with 92% fidelity, while maintaining 75% of its T2E. Improv
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