We obtain new Faber-Krahn-type inequalities for certain perturbations of the Dirichlet Laplacian on a bounded domain. First, we establish a two- and three-dimensional Faber-Krahn inequality for the Schrodinger operator with point interaction: the optimiser is the ball with the point interaction supported at its centre. Next, we establish three-dimensional Faber-Krahn inequalities for one- and two-body Schrodinger operator with attractive Coulomb interactions, the optimiser being given in terms of Coulomb attraction at the centre of the ball. The proofs of such results are based on symmetric decreasing rearrangement and Steiner rearrangement techniques; in the first model a careful analysis of certain monotonicity properties of the lowest eigenvalue is also needed.