We evaluate the differences of HOMFLY-PT invariants for pairs of mutant knots colored with representations of $SL(N)$, which are large enough to distinguish between them. These mutant pairs include the pretzel mutants, which require at least the representation, labeled by the Young diagram $[4,2]$. We discuss the differential expansion for the differences, it is non-trivial in the case of mutants, which have the non-zero defect. The most effective technical tool, in this case, turns out to be the standard Reshetikhin-Turaev approach.
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