Previous works for a liquid suddenly contacting a gas at a supercritical pressure show the coexistence of both phases and the generation of diffusion layers on both sides of the liquid-gas interface due to thermodynamic phase equilibrium. A related numerical study of a laminar mixing layer between the liquid and gas streams in the near field of the splitter plate suggests that mass, momentum and thermal diffusion layers evolve in a self-similar manner at very high pressures. In this paper, the high-pressure, two-phase, laminar mixing-layer equations are recast in terms of a similarity variable. A liquid hydrocarbon and gaseous oxygen are considered. Freestream conditions and proper matching conditions at the liquid-gas interface are applied. To solve the system of equations, a real-fluid thermodynamic model based on the Soave-Redlich-Kwong equation of state is selected. A comparison with results obtained by directly solving the laminar mixing-layer equations shows the validity of the similarity approach applied to non-ideal two-phase flows. Even when the gas is hotter than the liquid, condensation can occur at high pressures while heat conducts into the liquid. Finally, a generalized correlation is proposed to represent the evolution of the mixing layer thickness for different problem setups.