We address the question of minimal requirements for the existence of quantum bound states. In particular, we demonstrate that a few-body system with zero-range momentum-independent two-body interactions is unstable against decay into clusters, if mixed-symmetry of its wave function is enforced. We claim that any theory in which the two-body scattering length is much larger than any other scale involved exhibits such instability. We exemplify this with the inability of the leading-order pionless effective field theory to describe stable states of $A>4$ nuclei. A finite interaction range is identified as a sufficient condition for a bound mixed-symmetry system. The minimal value of this range depends on the proximity of a system to unitarity, on the number of constituents, and on the particular realization of discrete scale invariance of the three-body spectrum.
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