In this work we analyse the entanglement entropy in deep inelastic scattering off protons and nuclei. It is computed based on the formalism where the partonic state at small-x is maximally entangled with proton being constituted by large number of microstates occuring with equal probabilities. We consider analytical expressions for the number of gluons, N_{gluon}, obtained from gluon saturation models for the dipole-target amplitudes within the QCD color dipole picture. In particular, the nuclear entanglement entropy per nucleon is studied. We also study the underlying uncertainties on these calculations and compare the results to similar investigations in literature.