Novel liquid crystalline (LC) compositions are suggested and studied as elements of LC-nose. This allows for optical detection of several volatile organic compounds (VOCs). Ethanol, toluene, pyridine and acetic acid were detected by means of colorimetric and spectroscopic techniques during their diffusion inside chiral elements of LC-nose. Selectivity to different VOCs is enhanced by means of components of liquid crystal matrix with different viscosity, affinities to the solvents, and abilities to form hydrogen bonding.