Linear perturbations of spherically symmetric spacetimes in general relativity are described by radial wave equations, with potentials that depend on the spin of the perturbing field. In previous work we studied the quasinormal mode spectrum of spacetimes for which the radial potentials are slightly modified from their general relativistic form, writing generic small modifications as a power-series expansion in the radial coordinate. We assumed that the perturbations in the quasinormal frequencies are linear in some perturbative parameter, and that there is no coupling between the perturbation equations. In general, matter fields and modifications to the gravitational field equations lead to coupled wave equations. Here we extend our previous analysis in two important ways: we study second-order corrections in the perturbative parameter, and we address the more complex (and realistic) case of coupled wave equations. We highlight the special nature of coupling-induced corrections when two of the wave equations have degenerate spectra, and we provide a ready-to-use recipe to compute quasinormal modes. We illustrate the power of our parametrization by applying it to various examples, including dynamical Chern-Simons gravity, Horndeski gravity and an effective field theory-inspired model.