The KLOE-2 experiment at the INFN Laboratori Nazionali di Frascati (LNF) completed its data-taking at the $e^+ e^-$ DA$Phi$NE collider, which implements an innovative collision scheme based on a crab-waist configuration, and achieved the integrated luminosity of more than 5 fb$^-1$. KLOE-2 represents the continuation of KLOE with an upgraded detector and an extended physics program which includes, among the main topics, neutral kaon interferometry and test of discrete symmetries . Entangled neutral kaon pairs produced at DA$Phi$NE are a unique tool to test discrete symmetries and quantum coherence at the utmost sensitivity, strongly motivating the experimental searches of possible CPT violating effects, which would constitute an unambiguous signal of New Physics. The status of the test of Time reversal and CPT simmetry in $phi to mbox{K}_S mbox{K}_L to pi u,3pi^0,(2pi)$ decays with KLOE and KLOE-2 data will be discussed.
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