Utilizing the dataset corresponding to an integrated luminosity of $2.93$ fb$^{-1}$ at $sqrt{s}=3.773$ GeV collected by the BESIII detector, we report the first amplitude analysis and branching fraction measurement of the $D^0rightarrow K^-pi^+pi^0pi^0$ decay. We investigate the sub-structures and determine the relative fractions and the phases among the different intermediate processes. Our results are used to provide an accurate detection efficiency and allow measurement of ${cal B}(D^0rightarrow K^-pi^+pi^0pi^0) ,=, (8.86 pm 0.13(text{stat}) pm 0.19(text{syst}))%$.
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