Galaxy evolution is driven by many complex interrelated processes as galaxies accrete gas, form new stars, grow their stellar masses and central black holes, and subsequently quench. The processes that drive these transformations is poorly understood, but it is clear that the local environment on multiple scales plays a significant role. Todays massive clusters are dominated by spheroidal galaxies with low levels of star formation while those in the field are mostly still actively forming their stars. In order to understand the physical processes that drive both the mass build up in galaxies and the quenching of star formation, we need to investigate galaxies and their surrounding gas within and around the precursors of todays massive galaxy clusters -- protoclusters at z>2. The transition period before protoclusters began to quench and become the massive clusters we observe today is a crucial time to investigate their properties and the mechanisms driving their evolution. However, until now, progress characterizing the galaxies within protoclusters has been slow, due the difficulty of obtaining highly complete spectroscopic observations of faint galaxies at z>2 over large areas of the sky. The next decade will see a transformational shift in our understanding of protoclusters as deep spectroscopy over wide fields of view will be possible in conjunction with high resolution deep imaging in the optical and near-infrared.