In the past decades, the phenomenology of fast time variations of high-energy flux from black-hole binaries has increased, thanks to the availability of more and more sophisticated space observatories, and a complex picture has emerged. Recently, models have been developed to interpret the observed signals in terms of fundamental frequencies connected to General Relativity, which has opened a promising way to measure the prediction of GR in the strong-field regime. I review the current standpoint both from the observational and theoretical side and show that these systems are the most promising laboratories for testing GR and the observations available today suggest that the next observational facilities can lead to a breakthrough in the field.
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