We describe all groups that can be generated by two twists along spherical sequences in an enhanced triangulated category. It will be shown that with one exception such a group is isomorphic to an abelian group generated by not more than two elements, the free group on two generators or the braid group of one of the types $A_2$, $B_2$ and $G_2$ factorized by a central subgroup. The last mentioned subgroup can be nontrivial only if some specific linear relation between length and sphericity holds. The mentioned exception can occur when one has two spherical sequences of length $3$ and sphericity $2$. In this case the group generated by the corresponding two spherical twists can be isomorphic to the nontrivial central extension of the symmetric group on three elements by the infinite cyclic group. Also we will apply this result to give a presentation of the derived Picard group of selfinjective algebras of the type $D_4$ with torsion $3$ by generators and relations.
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