Precise spatial scaling in the early fly embryo

The early fly embryo offers a relatively pure version of the problem of spatial scaling in biological pattern formation. Within three hours, a blueprint for the final segmented body plan of the animal is visible in striped patterns of gene expression. We measure the positions of these stripes in an ensemble of 100+ embryos from a laboratory strain of Drosophila melanogaster, under controlled conditions. These embryos vary in length by only 4% (rms), yet stripes are positioned with 1% accuracy; precision and scaling of the pattern are intertwined. We can see directly the variation of absolute stripe positions with length, and the precision is so high as to exclude alternatives, such as combinations of unscaled signals from the two ends of the embryo.