Numerous work had been done to quantify the entanglement of a two-qubit quantum state, but it can be seen that previous works were based on joint measurements on two copies or more than two copies of a quantum state under consideration. In this work, we show that a single copy and two measurements are enough to estimate the entanglement quantifier like entanglement negativity and concurrence. To achieve our aim, we establish a relationship between the entanglement negativity and the minimum eigenvalue of structural physical approximation of partial transpose of an arbitrary two-qubit state. The derived relation make possible to estimate entanglement negativity experimentally by Hong-Ou-Mandel interferometry with only two detectors. Also, we derive the upper bound of the concurrence of an arbitrary two-qubit state and have shown that the upper bound can be realized in experiment. We will further show that the concurrence of (i) an arbitrary pure two-qubit states and (ii) a particular class of mixed states, namely, rank-2 quasi-distillable mixed states, can be exactly estimated with two measurements.
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