We report three-dimensional trapping of an oxide molecule (YO), using a radio-frequency magneto-optical trap (MOT). The total number of molecules loaded is $sim$1.5$times10^4$ , with a temperature of 7(1)~mK. This diversifies the frontier of molecules that are laser coolable and paves the way for the second-stage narrow-line cooling in this molecule to the microkelvin regime. Futhermore, the new challenges of creating a 3-D MOT of YO resolved here indicate that MOTs of more complex non-linear molecules should be feasible as well.
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