We present the first direct calculation of the transversity parton distribution function within the nucleon from lattice QCD. The calculation is performed using simulations with the light quark mass fixed to its physical value and at one value of the lattice spacing. Novel elements of the calculations are non-perturbative renormalization and extraction of a formula for the matching to light-cone PDFs. Final results are presented in the $overline{rm MS}$ scheme at a scale of $sqrt{2}$ GeV.