Within the differential equation method for multiloop calculations, we examine the systems irreducible to $epsilon$-form. We argue that for many cases of such systems it is possible to obtain nontrivial quadratic constraints on the coefficients of $epsilon$-expansion of their homogeneous solutions. These constraints are the direct consequence of the existence of symmetric $(epsilon+1/2)$-form of the homogeneous differential system, i.e., the form where the matrix in the right-hand side is symmetric and its $epsilon$-dependence is localized in the overall factor $(epsilon+1/2)$. The existence of such a form can be constructively checked by available methods and seems to be common to many irreducible systems, which we demonstrate on several examples. The obtained constraints provide a nontrivial insight on the structure of general solution in the case of the systems irreducible to $epsilon$-form. For the systems reducible to $epsilon$-form we also observe the existence of symmetric form and derive the corresponding quadratic constraints.
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