We make the first data release (DR1) of the ongoing ESO Public Survey SAMPLING (http://dx.doi.org/10.7910/DVN/0L8NHX). DR1 comprises of 124 fields distributed in $70^circ < l < 216^circ$, $-35^circ < b < 25^circ$. The 12CO and 13CO (2-1) cubes are gridded in $8$ pixels, with an effective resolution of $36$. The channel width is 0.33 km/s and the RMS noise is $T_{rm mb}<0.2$ K. Once completed, SAMPLING and complementary surveys will initiate the first major step forward to characterize molecular clouds and star formation on truly Galactic scales.