The relativistic kinetic theory approach has been employed to study four well-known transport coefficients that characterize heat flow and diffusion for the case of a hot mixture constituting of nucleons and pions. Medium effects on the cross-section for binary collisions ($Npi$,$pipi$) have been taken into consideration by incorporating self-energy corrections to modify the propagator of the exchanged $Delta$ baryon in $Npi$ interaction and the $rho$ and $sigma$ meson propagators for the case of $pipi$ interaction. The temperature dependence of the four coefficients have been investigated for several values of the baryon chemical potential.