Using the duality between color and kinematics, we construct two-loop four-point scattering amplitudes in $mathcal{N}=2$ super-Yang-Mills (SYM) theory coupled to $N_f$ fundamental hypermultiplets. Our results are valid in $Dle 6$ dimensions, where the upper bound corresponds to six-dimensional chiral $mathcal{N}=(1,0)$ SYM theory. By exploiting a close connection with $mathcal{N}=4$ SYM theory - and, equivalently, six-dimensional $mathcal{N}=(1,1)$ SYM theory - we find compact integrands with four-dimensional external vectors in both the maximally-helicity-violating (MHV) and all-chiral-vector sectors. Via the double-copy construction corresponding $D$-dimensional half-maximal supergravity amplitudes with external graviton multiplets are obtained in the MHV and all-chiral sectors. Appropriately tuning $N_f$ enables us to consider both pure and matter-coupled supergravity, with arbitrary numbers of vector multiplets in $D=4$. As a bonus, we obtain the integrands of the genuinely six-dimensional supergravities with $mathcal{N}=(1,1)$ and $mathcal{N}=(2,0)$ supersymmetry. Finally, we extract the potential ultraviolet divergence of half-maximal supergravity in $D=5-2epsilon$ and show that it non-trivially cancels out as expected.
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