In this paper, we suggest a framework to make use of mutual information as a regularization criterion to train Auto-Encoders (AEs). In the proposed framework, AEs are regularized by minimization of the mutual information between input and encoding variables of AEs during the training phase. In order to estimate the entropy of the encoding variables and the mutual information, we propose a non-parametric method. We also give an information theoretic view of Variational AEs (VAEs), which suggests that VAEs can be considered as parametric methods that estimate entropy. Experimental results show that the proposed non-parametric models have more degree of freedom in terms of representation learning of features drawn from complex distributions such as Mixture of Gaussians, compared to methods which estimate entropy using parametric approaches, such as Variational AEs.