Purpose: Spatio-temporal encoding (SPEN) experiments can deliver single-scan MR images without folding complications and with robustness to chemical shift and susceptibility artifacts. It is here shown that further resolution improvements can arise by relying on multiple receivers, to interpolate the sampled data along the low-bandwidth dimension. The ensuing multiple-sensor interpolation is akin to recently introduced SPEN interleaving procedures, albeit without requiring multiple shots. Methods: By casting SPENs spatial rasterization in k-space, it becomes evident that local k-data interpolations enabled by multiple receivers are akin to real-space interleaving of SPEN images. The practical implementation of such resolution-enhancing procedure becomes similar to those normally used in SMASH or SENSE, yet relaxing these methods fold-over constraints. Results: Experiments validating the theoretical expectations were carried out on phantoms and human volunteers on a 3T scanner. The experiments showed the expected resolution enhancement, at no cost in the sequences complexity. With the addition of multibanding and stimulated echo procedures, 48-slices full-brain coverage could be recorded free from distortions at sub-mm resolution, in 3 sec. Conclusion: Super-resolved SPEN with SENSE (SUSPENSE) achieves the goals of multi-shot SPEN interleaving within one single scan, delivering single-shot sub-mm in-plane resolutions in scanners equipped with suitable multiple sensors.
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