The observed constraints on the variability of the proton to electron mass ratio $mu$ and the fine structure constant $alpha$ are used to establish constraints on the variability of the Quantum Chromodynamic Scale and a combination of the Higgs Vacuum Expectation Value and the Yukawa couplings. Further model dependent assumptions provide constraints on the Higgs VEV and the Yukawa couplings separately. A primary conclusion is that limits on the variability of dimensionless fundamental constants such as $mu$ and $alpha$ provide important constraints on the parameter space of new physics and cosmologies.
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