With progress in quantum technology more sophisticated quantum annealing devices are becoming available. While they offer new possibilities for solving optimization problems, their true potential is still an open question. As the optimal design of adiabatic algorithms plays an important role in their assessment, we illustrate the aspects and challenges to consider when implementing optimization problems on quantum annealing hardware based on the example of the traveling salesman problem (TSP). We demonstrate that tunneling between local minima can be exponentially suppressed if the quantum dynamics are not carefully tailored to the problem. Furthermore we show that inequality constraints, in particular, present a major hurdle for the implementation on analog quantum annealers. We finally argue that programmable digital quantum annealers can overcome many of these obstacles and can - once large enough quantum computers exist - provide an interesting route to using quantum annealing on a large class of problems.
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