The strangeness $S=-2$ baryon-baryon interaction is investigated directly from the fundamental theory of the strong interaction, QCD. The HAL QCD method enables us to extract baryon interactions from the Nambu-Bethe-Salpeter wave functions without using any experimental information. We present our latest result on the $S = -2$ baryon interactions and discuss the H-dibaryon state using potentials which are calculated by using the (almost) physical point gauge configurations with large lattice volume of$(8.1{rm{fm}})^4$ generated on the K-computer.
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