We present an analysis of the gamma-ray measurements by the Large Area Telescope onboard the textit{Fermi Gamma-ray Space Telescope} in the region of the supernova remnant~(SNR) Monoceros Loop~(G205.5$+$0.5). The brightest gamma-ray peak is spatially correlated with the Rosette Nebula, which is a molecular cloud complex adjacent to the southeast edge of the SNR. After subtraction of this emission by spatial modeling, the gamma-ray emission from the SNR emerges, which is extended and fit by a Gaussian spatial template. The gamma-ray spectra are significantly better reproduced by a curved shape than a simple power law. The luminosities between 0.2--300~GeV are $sim$~$4 times 10^{34}$~erg~s$^{-1}$ for the SNR and $sim$~$3 times 10^{34}$~erg~s$^{-1}$ for the Rosette Nebula, respectively. We argue that the gamma rays likely originate from the interactions of particles accelerated in the SNR. The decay of neutral pions produced in nucleon-nucleon interactions of accelerated hadrons with interstellar gas provides a reasonable explanation for the gamma-ray emission of both the Rosette Nebula and the Monoceros SNR.
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